Plasma cholinesterase has been called pseudocholinesterase, because it hydrolyzes many -esters, as well as acetylcholine.
Pseudocholinesterase, which is mainly distributed in the serum, is synthesized in parallel
with serum albumin by the liver and is reduced by liver injury or liver disease.
Many observations have been suggested that measurement of pseudocholinesterase may
be of value in following the course of liver disease or estimation of liver function.
The purposes of this study were to investigate the normal plasma cholinesterase activity
.and to evaluate it as a test of liver function.
Eighty patients without abnormal liver function in physical status I (adopted by American Society of Anesthesiologists) and thirty two cancer patients, aged from 20 to 69 years were studied.
Venous blood was collected before induction, placed in heparinized tubes, centrifuged and the plasma stored at 4C until assayed. The plasma cholinesterase value was measured by Wako kit and JASCO UVIDEC 77 clinical spectrophotometer.
The results are as follows;
1. In normal subjects, mean value of plasma cholinesterase v.-as 1271.3201.6 IU/1 and normal range was 866-1677 IU/1.
2. In cancer patients, mean value of plasma cholinesterase was 948.8123.9 IU/1.
3. The result of measuring correlation coefficient of plasma cholinesterase and liver fun-,ction tests revealed that albumin had the most significant correlation.
4. The result of comparison of liver function tests of cancer patients against normal per-sons showed that plasma cholinesterase decreased and cholesterol and alkaline phosphatase increased.
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